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In The Scientific Sherlock Holmes, James O'Brien provides an in-depth look at Sherlock Holmes's use of science in his investigations. Indeed, one reason for Holmes's appeal is his frequent use of the scientific method and the vast scientific knowledge which he drew upon to solve mysteries. For instance, in heart of the audiobook, the author reveals that Holmes was a pioneer of forensic science, making use of fingerprinting well before Scotland Yard itself had adopted the method.

Forensic expert Wagner has crafted a volume that stands out from the plethora of recent memoirs of contemporary scientific detectives. By using the immortal and well-known Sherlock Holmes stories as her starting point, Wagner blends familiar examples from Doyle's accounts into a history of the growth of forensic science, pointing out where fiction strayed from fact.

After a wealthy woman was brutally murdered in her Glasgow home in 1908, the police found a convenient suspect in Oscar Slater, an immigrant Jewish cardsharp. Though he was known to be innocent, Slater was tried, convicted, and consigned to life at hard labor. Outraged by this injustice, Arthur Conan Doyle, already world famous as the creator of Sherlock Holmes, used the methods of his most famous character to reinvestigate the case, ultimately winning Slater’s freedom.

"The Adventure of the Red Circle" is one of the 56 Sherlock Holmes short stories written by Sir Arthur Conan Doyle, and one of eight stories in the volume, His Last Bow. Sir Arthur Conan Doyle (May 22, 1859 - July 7, 1930) was a British author most noted for his stories about the detective Sherlock Holmes, which are generally considered a major innovation in the field of crime fiction.